Abnormal sulfate metabolism in vitamin D-deficient rats.

Nov 01, 1997 · The ability of vitamin D status to regulate Na-SO4 cotransport appears to be a direct effect, and is not mediated by the effects of vitamin D on plasma calcium or parathyroid hormone levels. Because sulfate is required for synthesis of essential matrix components, abnormal sulfate metabolism in vitamin D-deficient.

JCI - Abnormal sulfate metabolism in vitamin D-deficient rats.

These results demonstrate that vitamin D modulates renal Na-SO4 sulfate cotransport and sulfate homeostasis. The ability of vitamin D status to regulate Na-SO4 cotransport appears to be a direct effect, and is not mediated by the effects of vitamin D on plasma calcium or parathyroid hormone levels.

PDF Abnormal sulfate metabolism in vitamin D-deficient rats

Because sulfate is required for synthesis of essential matrix components, abnormal sulfate metabolism in vitamin D-deficient animals may contribute to producing some of the abnormalities observed. Critical role of vitamin D in sulfate homeostasis. Vitamin D deficiency in rats leads to lower serum sulfate levels and decreased NaSi-1 expression, but sulfate metabolism in vitamin D receptor (VDR)-deficient animals has not been reported. In the present study, we used VDR knockout mice as a model to further investigate the role of vitamin D in sulfate.Magnesium Required for Vitamin D SupplementsHeal Naturally The bottom line is if you are taking vitamin D supplements, make sure you also have enough magnesium in your diet to absorb and metabolize that vitamin D. In terms of supplementing vitamin D, many nutritionists agree that healthy doses of vitamin D range about 4,000 IU per day or even higher.Why Vitamin D3 Supplements May Not Replace Sunshine May 01, 2012 · This process yields Vitamin D sulfate, which according to Dr. Seneff is vastly different than plant-based Vitamin D2 and animal-based Vitamin D3. Upon exposure to the sun, the skin synthesizes vitamin D3 Sulfate, a form of vitamin D that, unlike unsulfated vitamin D3, is water soluble.Vitamin D: Metabolism - PubMed Central PMC I. SYNTHESIS OF 1,25(OH) 2 D 3 FROM VITAMIN D 3 Vitamin D 3 (cholecalciferol) is taken in the diet (from fortified dairy products and fish oils) or is synthesized in the skin from 7-dehydrocholesterol by ultraviolet irradiation. The vitamin D produced by 7-dehydrocholesterol depends on the intensity of.Metabolic activities of vitamin D in animals. 6. For parts 3 and 4 see Abst. 4174, Vol. 36. 6. Intraperitoneal injection of mice with the sodium or ammonium salt of vitamin D2 sulfate showed it to be less toxic than free vitamin D2. The LD50 value was estimated to be 2.5 x 106 IU per kg. Three groups of rats were fed on the Steenbock diet for 8 weeks, with which one group received 10 IU vitamin.
  • What’s the Relationship Between Vitamin D and Cholesterol?
  • The main function of vitamin D is to promote calcium absorption in your body. You can get vitamin D through your diet and by getting out in the sun, as long as you don’t have sunscreen on. Sunscreens (especially SPF 8 or higher) block the skin’s absorption of the vitamin.

    Chromatographic separation of vitamin D3 sulfate and.

    One technical approach to the study of the sulfoconjugate of vitamin D was to carry out chemically or enzymatically desulfatation and then determination of the vitamin D liberated (10). However, none of these techniques is appropriate to study subsequent metabolism of tracer doses of vitamin D sulfate.

  • 12 Ways to Get Your Daily Vitamin D - Health
  • Jan 26, 2016 · Vitamin D supplements can help you get your proper daily dose, and as Dr. Honig points out, you don't run into the issue of skin cancer as you might with UV rays. "And it's not like calcium," he says.

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